Nobel Prize in Chemistry: How protein discoveries benefit research at BASF

• Computational protein design and protein structure prediction speed up day-to-day research
• Software can help predict, design, and optimize proteins for new plant traits and crop protection products

On December 10, the Royal Swedish Academy of Sciences will award this year’s Nobel Prizes in Stockholm, Sweden. The prizes for chemistry this year are all about proteins, considered the building blocks of life. David Baker (University of Washington, Seattle, USA; Howard Hughes Medical Institute, USA) who is awarded with one half of the Nobel Prize, succeeded in building entirely new proteins with the help of the computer software Rosetta. Demis Hassabis and John Jumper (both Google DeepMind, London, United Kingdom) are jointly awarded with the other half of the Nobel Prize for the development of AlphaFold2, an artificial intelligence (AI) model that predicts proteins’ complex structures.

Both discoveries hold enormous potential for BASF, where understanding protein structure has been fundamental for developing new products for decades. With the help of new technologies like Rosetta and AlphaFold2 researchers can now better predict, design and optimize for example new plant traits and crop protection products – potentially faster and with even better efficacy than with conventional protein structure prediction tools. “It can take decades to develop a new trait that makes crops resistant to pests, or to create a new chemistry that controls diseases, pests or weeds. Protein research is critical to trait and crop protection R&D, and we are already leveraging these new AI tools to accelerate the development of effective solutions for farmers and our food supply,” says Dr. Jürgen Huff, Senior Vice President Global R&D and Regulatory at BASF Agricultural Solutions. “As an innovation driven company benefitting from their work, we congratulate the laureates for their awards”.

The possibility to design new protein sequences after having an accurate three-dimensional structure streamlines BASF’s protein engineering and design pipeline. “Being able to predict protein structure enables the early adoption of several computational tools for protein modelling at the beginning of a research project,” says Dr. Stefan Seemayer, Team lead for computational protein engineering at BASF. “We can calculate thousands of hypotheses, for example for the most effective trait to confer resistance to a pest, and select high-quality designs from the generated ones, reducing our testing efforts,” he adds.

The code for Rosetta is publicly available, so a global research community has continued to develop the software since its publication in 2003, finding new areas of application. The Nobel Committee also acknowledged that AlphaFold2 is being used by more than two million people from 190 countries.

About BASF’s Agricultural Solutions division

Everything we do, we do for the love of farming. Farming is fundamental to provide enough healthy and affordable food for a rapidly growing population, while reducing environmental impacts. That’s why we are working with partners and experts to integrate sustainability criteria into all business decisions. With €900 million in 2023, we continue to invest in a strong R&D pipeline, combining innovative thinking with practical action in the field. Our solutions are purpose-designed for different crop systems. Connecting seeds and traits, crop protection products, digital tools and sustainability approaches, to help deliver the best possible outcomes for farmers, growers and our other stakeholders along the value chain. With teams in the lab, field, office and in production, we do everything in our power to build a sustainable future for agriculture. In 2023, our division generated sales of €10.1 billion. For more information, please visit www.agriculture.basf.com or any of our social media channels.

About BASF

At BASF, we create chemistry for a sustainable future. We combine economic success with environmental protection and social responsibility. Around 112,000 employees in the BASF Group contribute to the success of our customers in nearly all sectors and almost every country in the world. Our portfolio comprises six segments: Chemicals, Materials, Industrial Solutions, Surface Technologies, Nutrition & Care, and Agricultural Solutions. BASF generated sales of €68.9 billion in 2023. BASF shares are traded on the stock exchange in Frankfurt (BAS) and as American Depositary Receipts (BASFY) in the United States. Further information at www.basf.com.